Engineered Magnetobacterial Microrobots with Tunable Self-Mineralization for Precise Imaging-Guided Photothermal Therapy

studies demonstrate that BAMs can migrate to the hypoxic core of the tumors through the synergistic effect of hypoxia-targeting chemotaxis and magnetic actuation, which can be monitored via NIR-II fluorescence imaging. Moreover, as a photothermal therapeutic agent, BAMs effectively induce tumor cell apoptosis and suppress tumor growth through photothermal conversion. This innovative BAMs platform not only overcomes passive diffusion but also provides precise theranostics through integrated magnetic guidance, NIR-II imaging, and photothermal therapy, showcasing the promise of biohybrid systems.