医学
心外膜脂肪组织
逻辑回归
内科学
脂肪组织
胃肠病学
计算机断层摄影术
2019年冠状病毒病(COVID-19)
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
外科
疾病
传染病(医学专业)
作者
Pınar Türker Duyuler,Serkan Duyuler,Bekir Demirtaş,Velihan Cayhan
标识
DOI:10.1080/00015385.2021.2010009
摘要
Objective To investigate the association between epicardial and pericoronary adipose tissue thicknesses measured with computed tomography (CT) and severity of COVID-19 infection.Methods We recruited 504 patients admitted with RT-PCR-proven diagnosis of COVID-19 infection and underwent simultaneous Chest CT scanning. Epicardial adipose tissue thickness (EAT) and pericardial adipose tissue thickness (PCAT) were measured by CT. Comparisons were performed between ICU admitting and non-ICU admitting patients were performed.Results Of 504 patients, 423 patients were hospitalised in normal wards or followed as outpatient, and 81 patients were admitted to ICU. EAT and PCAT were significantly increased in ICU patients (5.98[5.06–7.13] mm vs. 8.05[6.90–9.89] mm, p < 0.001 and 9.3[7.4–11.5] mm vs. 11.2[10.3–13.2] mm, p < 0.001, respectively). In multiple logistic regression analyses, EAT and PCAT were independent predictors of ICU admission. A cut-off point of 6.64 mm EAT has a sensitivity of 82.7% and a specificity of 66.7% (AUC = 0.789, 95% CI: 0.744–0.833, p < 0.001) and a cut-off point of 9.85 mm PCAT has a sensitivity of 91.4% and a specificity of 61.2% (AUC = 0.744, 95% CI: 0.700–0.788, p < 0.001).Conclusion We found that both increased EAT and PCAT were associated with the severity of COVID-19 infection defined as the need for ICU admission.
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