胶束
两亲性
化学
高分子化学
聚氨酯
化学工程
乙二醇
临界胶束浓度
共聚物
聚合物
有机化学
肺表面活性物质
动态光散射
作者
Peng Zhang,Jiaying Hu,Leran Bu,Hena Zhang,Bai-Xiang Du,Caihong Zhu,Yuling Li
出处
期刊:Polymers
[MDPI AG]
日期:2019-02-04
卷期号:11 (2): 262-262
被引量:5
标识
DOI:10.3390/polym11020262
摘要
In this paper, we synthesized a biodegradable amphiphilic polymer of polyurethane-polyethylene glycol with disulfide bonds in the main chain (PEG-PU(SS)-PEG). DLS and SEM showed that the polymer could self-assemble into micelles in aqueous solution and could be used to load the hydrophobic anticancer drug DOX. Intriguingly, drug release in vitro indicated that DOX-loaded PEG-PU(SS)-PEG micelles had good stability under the extracellular physiological environment, but the disulfide bonds broke rapidly and DOX was released quickly under the intracellular reducing conditions. CCK-8 assays showed that DOX-loaded PEG-PU(SS)-PEG micelles had a high in vitro antitumor activity in C6 cells, whereas blank PEG-PU(SS)-PEG micelles were nontoxic to C6 cells. It was also found that there was strong and persistent accumulation of DOX-loaded PEG-PU(SS)-PEG as compared with PEG-PU-PEG both by the cell internalization tests and the flow cytometry measurements. Hence, PEG-PU(SS)-PEG micelles will have a potential use for clinical treatment of cancer in the future.
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