Because of un-rational use of antibiotics,the antibiotic-associated colitis has greatly increased day by day.Symptomatic therapy,adjustment of antibiotics is the normal treatment of antibiotic-associated colitis,but it is easy to recur.The effective treatment of antibiotic-associated colitis,should put emphasis on maintaining normal intestinal flora based on antibiotic therapy,in which vitamins and micro-ecologic products have great application future in its therapy.