Objective To investigate the clinical efficacy of etanercept,sulfasalazine combined with functional exercise in the treatment of ankylosing spondylitis. Methods Seventy patients diagnosed with ankylosing spondylitis in our hospital from July 2010 to July 2012 were randomly divided into the observation group and the control group,with 35 patients in each group. The control group only received etanercept and sulfasalazine medication and the observation group received additional functional exercise on the basis of the control group. One treatment course consisted of 3 months. The two groups were compared and analyzed after treatment. Results After 1 treatment course,clinical symptoms of the two groups relieved to varying degrees;But the observation group was significantly higher than thec ontrol group in the total effective rate,with statistically significant difference between the two groups (P0.05).Conclusion Etanercept,sulfasalazine combined with functional exercise shows accurate clinical efficacy,good safety and few adverse reactions in the treatment of ankylosing spondylitis,thereby worth further clinical promotion and application.