Living 4-6 week-aged San Yuan white pigs (Suzhou, China) were used in skin decontamination experiments. Following a standard procedure, SM series of decontamination agents were used for decontamination of liquid nuclides. The results of immediate decontamination were as follows: K(decontamination efficiency) = 97. 7% (decontamination factor DF = 43. 5) for 131I; K 99% (DF100) for 90Sr/90Y, MFP and U+TRU; K =99. 9% (DF = 1000) for 137Cs. In 3 h-delayed decontamination,DF = 27-67 ( K =96. 3%-98. 5%) for the nuclides mentioned above. When the initiatory MFP contamination increased from 20 to 300 s-1 . cm-2, the value of DF by immediate decontamination increased from 20 to 173 with the remaining activity not higher than 10 Bq . cm-2, and no additional decontamination was needed. For radioactive ash contamination of skin, DF=57-1000 ( K =:98. 2%-99. 9%) in 4 h-delayed decontamination. SM series of decontamination agents are neutral liquid or cream without any irritative effect on skin. They are effective and easy to use in skin decontamination.