Experimental Study on Sedative and Hypnotic Effects of Tianwang Buxin Wan

Objective:To investigate the sedative and hypnotic effects of Tianwang Buxin Wan(TWBXW)on mice model.Method: ICR rats were divided into five groups randomly,three dose groups of TWBXW(3.24,1.62,0.81 g·kg-1),control group and Annao Jianshen group.Spontancous locomotor activities of mice in five minutes,precentage of sleep,sleep latency,maintaining sleep were evaluated.The effects of TWBXW on spontaneous locomotor activities in normal mice group and yin deficiency mice group were observed.Hypnotic effects were assayed by cooperated with pentobarbital sodium.Result: There was no direct influence of TWBXW on the spontaneous locomotor activity in normal mice.But it could significantly decrease the spontaneous locomotor activity of mice with yin deficiency syndrome.TWBXW could reduce sleep latency and extend sleep time induced by pentobarbital sodium.Conclusion:TWBXW showed certain sedative and hypnotic effects.