内质网
甾醇调节元件结合蛋白
未折叠蛋白反应
转录因子
细胞生物学
平衡
化学
脂质代谢
胆固醇
内质网相关蛋白降解
生物
生物化学
基因
作者
Stephen Colgan,Ali Al‐Hashimi,Richard C. Austin
出处
期刊:Expert Reviews in Molecular Medicine
[Cambridge University Press]
日期:2011-02-01
卷期号:13
被引量:80
标识
DOI:10.1017/s1462399410001742
摘要
Cellular cholesterol homeostasis is a fundamental and highly regulated process. Transcription factors known as sterol regulatory element binding proteins (SREBPs) coordinate the expression of many genes involved in the biosynthesis and uptake of cholesterol. Dysregulation of SREBP activation and cellular lipid accumulation has been associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). This review will provide an overview of ER stress and the UPR as well as cholesterol homeostasis and SREBP regulation, with an emphasis on their interaction and biological relevance.
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