病菌
生物
寄主(生物学)
疾病
传染病(医学专业)
有机体
免疫学
防御机制
免疫系统
主机响应
生态学
医学
遗传学
病理
基因
作者
Ruslan Medzhitov,David Schneider,Miguel P. Soares
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2012-02-24
卷期号:335 (6071): 936-941
被引量:1330
标识
DOI:10.1126/science.1214935
摘要
The immune system protects from infections primarily by detecting and eliminating the invading pathogens; however, the host organism can also protect itself from infectious diseases by reducing the negative impact of infections on host fitness. This ability to tolerate a pathogen's presence is a distinct host defense strategy, which has been largely overlooked in animal and human studies. Introduction of the notion of "disease tolerance" into the conceptual tool kit of immunology will expand our understanding of infectious diseases and host pathogen interactions. Analysis of disease tolerance mechanisms should provide new approaches for the treatment of infections and other diseases.
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