化学
芳基
催化作用
试剂
镍
卤化物
钯
烷基
锌
质子
药物化学
无机化学
有机化学
量子力学
物理
作者
Georg Manolikakes,Carmen Muñoz Hernandez,Matthias A. Schade,Albrecht Metzger,Paul Knochel
摘要
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.
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