골 조직 재생을 위한 세라믹 인공지지체의 기계적 특성 향상

Calcium phosphate bioceramics including hydroxyapatite (HA) and tricalcium phosphate (TCP) are always discussed in relation with bone tissue regeneration because these two materials are the main inorganic components of bone tissue. Furthermore, biphasic calcium phosphate, mixture of HA and TCP, is well known as an osteoinductive material. Although bioceramics has a lot of advantages such as biocompatibility, osteoconductivity, biodegradability, etc. for bone tissue regeneration, mechanical properties of scaffolds fabricated from bioceramics are poor stable. In this study, we fabricated the 3 dimensional bioceramic scaffolds which has controlled inner and outer architecture using projection based microstereolithography. And cellular behaviors on the bioceramic scaffold were observed. After that, to improve the mechanical properties of scaffolds, we injected polycaprolactone (PCL) in the pores between bioceramic particles and evaluated the mechanical properties of scaffolds.