自愈水凝胶
伤口愈合
血管生成
透明质酸
透明质酸酶
抗菌活性
体内
乙二醇
化学
金黄色葡萄球菌
材料科学
高分子化学
酶
生物化学
有机化学
外科
细菌
医学
癌症研究
遗传学
生物技术
解剖
生物
作者
Chao Zhou,Chengju Sheng,Jinjie Chen,Yunhong Liang,Qingping Liu,Peng Li,Xiaodan Huang,Bo Liu
标识
DOI:10.1016/j.cej.2022.138200
摘要
Full-thickness skin defect wound infection seriously threatens the life and health of patients. Highly efficient antibacterial activity and angiogenesis after injury are critical for the wound healing process. In this work, we first designed various of halogen-free imidazolium poly(ionic liquids) (PILs) as the antibacterial agents, and selected the highest efficient antibacterial PIL. Then, we fabricated hyaluronic acid/poly(ethylene glycol)/PILs semi interpenetrating polymer network (semi-IPN) wound dressings by Diels-Alder (DA) click reaction, and deferoxamine (DFO) which promoted angiogenesis was grafted into the hydrogel wound dressings. In vitro and in vivo assays respectively evaluated the fast antibacterial property of the hydrogels against Escherichia coli and Staphylococcus aureus at skin infected wound areas. With the hydrogels enzymatic degradation by hyaluronidase, the degradation solution could reduce inflammation, promote angiogenesis and wound healing due to the continuous releasing of DFO and PIL. The programable hydrogel degradation protocol provided a new strategy for rapid full-thickness skin defect wound healing in the clinic application.
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