Anorexia is defined as a lack or loss of appetite. It frequently occurs post-hibernation and the phrase post-hibernation anorexia (PHA) has been coined, implying that this is a separate condition. PHA is simply anorexia occurring in the period immediately post-hibernation. It should be investigated and treated as per anorexia at any other stage of the year – the causes are much the same. This chapter discusses prognostic indicators and differential diagnoses of anorexia. It also discusses the therapy for the depleted chelonian.