同源盒
同源框A1
生物
遗传学
基因
毒力
HNF1B型
同源框蛋白Nkx-2.5
基因家族
作者
Yuming Ma,Jingya Zhao,Wenbo Chen,Xuejing Geng,Tianli He,Shengli Ding,Bingjian Sun,Honglian Li,Linlin Chen
标识
DOI:10.1007/s10528-021-10150-y
摘要
Homeobox transcription factors have been implicated in filamentous growth, conidia formation and virulence in fungal pathogens. However, the presence of the homeobox gene family and their potential influence on pathogenesis in Fusarium pseudograminearum have not been investigated. F. pseudograminearum is an important plant pathogen that causes wheat and barley crown rot. In this study, we performed a genome-wide survey for F. pseudograminearum homeobox genes, and 11 FpHtfs were identified and characterized. Domain analyses revealed that all of these proteins contain a complete homeobox domain that contains three helices. Expression profiles of FpHtf genes at different pathogen stages showed that six FpHtf genes were induced during infection. Further, we generated and characterized FpHtf3 deletion mutants in F. pseudograminearum, showing it was essential for virulence. These results indicated that members of the homeobox gene family are likely involved in F. pseudograminearum pathogenicity. Our work also provides a useful foundation for further studies on the complexity and function of the homeobox gene family in F. pseudograminearum.
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