O-GlcNAcylation of UGDH: emerging insights into immunometabolic regulation and therapeutic implications

作者
Qiang Wu,Ting Lei,Shujing Wang
出处
期刊:Cell death discovery [Springer Nature]
卷期号:12 (1)
标识
DOI:10.1038/s41420-026-03086-y
摘要

Lin B, Zhou J, Geng D, Chai S, Zhang X, Zhang Z, et al. O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular matrix to facilitate tumor growth. Cell Death Differ. 2025. https://doi.org/10.1038/s41418-025-01591-8 . Google Scholar Zhu Q, Wang H, Chai S, Xu L, Lin B, Yi W, et al. O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation. Proc Natl Acad Sci USA. 2023;120:e2216796120. https://doi.org/10.1073/pnas.2216796120 . Google Scholar Zhan D, Yalcin F, Ma D, Fu Y, Wei S, Lal B, et al. Targeting UDP-α-d-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth. Genes Dis. 2022;9:717–30. https://doi.org/10.1016/j.gendis.2021.08.008 . Google Scholar Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, et al. KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer. Cancer Cell. 2019;35:559–72.e557. https://doi.org/10.1016/j.ccell.2019.02.008 . Google Scholar Martinez-Ordoñez A, Duran A, Ruiz-Martinez M, Cid-Diaz T, Zhang X, Han Q, et al. Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Cancer Cell. 2023;41:252–71.e259. https://doi.org/10.1016/j.ccell.2022.11.016 . Google Scholar Hart GW, Housley MP, Slawson C. Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature. 2007;446:1017–22. https://doi.org/10.1038/nature05815 . Google Scholar Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL, et al. O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway. Mol Cell. 2014;54:820–31. https://doi.org/10.1016/j.molcel.2014.04.026 . Google Scholar Cheng SS, Mody AC, Woo CM. Opportunities for therapeutic modulation of O-GlcNAc. Chem Rev. 2024;124:12918–3019. https://doi.org/10.1021/acs.chemrev.4c00417 . Google Scholar Kuczek DE, Larsen AMH, Thorseth ML, Carretta M, Kalvisa A, Siersbæk MS, et al. Collagen density regulates the activity of tumor-infiltrating T cells. J Immunother Cancer. 2019;7:68 https://doi.org/10.1186/s40425-019-0556-6 . Google Scholar Yin H, Zhu J. Methods for quantification of glycopeptides by liquid separation and mass spectrometry. Mass Spectrom Rev. 2023;42:887–917. https://doi.org/10.1002/mas.21771 . Google Scholar Stromnes IM, Schmitt TM, Hulbert A, Brockenbrough JS, Nguyen H, Cuevas C, et al. T cells engineered against a native antigen can surmount immunologic and physical barriers to treat pancreatic ductal adenocarcinoma. Cancer Cell. 2015;28:638–52. https://doi.org/10.1016/j.ccell.2015.09.022 . Google Scholar Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, et al. Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors. Cancer Cell. 2019;35:885–900. https://doi.org/10.1016/j.ccell.2019.05.004 . Google Scholar Yang X, Qian K. Protein O-GlcNAcylation: emerging mechanisms and functions. Nat Rev Mol Cell Biol. 2017;18:452–65. https://doi.org/10.1038/nrm.2017.22 . Google Scholar Sun K, Zhi Y, Ren W, Li S, Zheng J, Gao L, et al. Crosstalk between O-GlcNAcylation and ubiquitination: a novel strategy for overcoming cancer therapeutic resistance. Exp Hematol Oncol. 2024;13:107 https://doi.org/10.1186/s40164-024-00569-5 . Google Scholar Bodenmiller B, Zunder ER, Finck R, Chen TJ, Savig ES, Bruggner RV, et al. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol. 2012;30:858–67. https://doi.org/10.1038/nbt.2317 . Google Scholar Download references

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
123完成签到,获得积分10
刚刚
刚刚
渡人舟的应助被56789采纳,获得30
1秒前
2秒前
alan的应助被6d采纳,获得20
2秒前
ganhhh完成签到,获得积分10
3秒前
愤怒的熊发布了新的文献求助10
3秒前
王浦轩发布了新的文献求助30
4秒前
在水一方的应助被科研小白狗采纳,获得20
4秒前
4秒前
英俊雁兰发布了新的文献求助10
4秒前
珊珊完成签到,获得积分10
4秒前
orixero的应助被老实的从雪采纳,获得10
5秒前
许娜发布了新的文献求助10
5秒前
5秒前
5秒前
飞鞚发布了新的文献求助10
5秒前
WANG发布了新的文献求助20
6秒前
顺利凡阳完成签到 ,获得积分10
6秒前
Arjun发布了新的文献求助10
7秒前
7秒前
罗罗罗完成签到,获得积分10
8秒前
晨阳完成签到,获得积分20
10秒前
小二郎的应助被niulugai采纳,获得10
12秒前
李哈哈发布了新的文献求助10
13秒前
田様的应助被zhangyupei采纳,获得10
13秒前
占曼荷完成签到,获得积分10
14秒前
14秒前
14秒前
14秒前
大模型的应助被是阿瑾呀采纳,获得10
14秒前
高LL发布了新的文献求助10
16秒前
科研通AI6.2的应助被56789采纳,获得10
17秒前
17秒前
LiiiY发布了新的文献求助10
17秒前
wuming完成签到,获得积分0
19秒前
汉堡包的应助被飞鞚采纳,获得10
19秒前
20秒前
昼屿发布了新的文献求助10
20秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Energie-Contracting 1500
Spec 401: Standards for Jet Fuel Facility and Equipment Commissioning and Flushing at Airports, 2026.1 (Original Issue) 1000
Spec 103: Standard for Jet Fuel Quality Control at Airports, Revision 2026.1 1000
Klimaschutzrecht durch den Energiesektor im Mehrebenensystem – Ein Rechtsvergleich 1000
二维钙钛矿人工光电突触的可塑性及应用的研究 500
Topological Photonics: Fundamentals and Applications 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 计算机科学 工程类 有机化学 化学工程 生物化学 物理 复合材料 内科学 催化作用 光电子学 人工智能 细胞生物学 无机化学 物理化学 数学
热门帖子
关注 科研通微信公众号,转发送积分 8095502
求助须知:如何正确求助?哪些是违规求助? 9506881
关于积分的说明 21457203
捐赠科研通 7669376
什么是DOI,文献DOI怎么找? 3406335
关于科研通互助平台的介绍 2534382
邀请新用户注册赠送积分活动 2445834