区域选择性
电泳剂
化学
芳基
亲电取代
吡啶
亲电芳香族取代
苯
药物化学
有机化学
组合化学
催化作用
烷基
作者
Rong L. Zhai,Yun Xue,Ting Liang,Jia J. Mi,Zhou Xu
标识
DOI:10.1021/acs.joc.8b01388
摘要
A direct regioselective functionalization of arenes and heteroarenes using N-alkenoxypyridinium salts as electrophilic alkylating agents for the synthesis of α-aryl/heteroaryl ketones has been developed. The method generates alkylating agents from alkynes and N-pyridine oxide followed by site-selective electrophilic substitution with a broad range of arenes and heteroarenes including benzene derivates, phenols, ethers, indoles, pyrroles, furans, and thiophenes in one pot. Kinetic isotope effect measurements and DFT studies reveal that this reaction likely proceeds through a carbon-cation intermediate.
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