单核细胞增生李斯特菌
微生物学
肠沙门氏菌
细胞内
细胞内寄生虫
沙门氏菌
磷霉素
生物
细菌
细胞外
抗生素
生物化学
遗传学
作者
Nobuhiko Okada,Miki Nishio,Hirofumi Danbara
出处
期刊:Chemotherapy
[S. Karger AG]
日期:2003-01-01
卷期号:49 (1-2): 49-55
被引量:6
摘要
We studied the effect of fosfomycin (FOM) on the intracellular growth of two different facultative intracellular bacteria, Salmonella enterica serovar Typhimurium and Listeria monocytogenes, in an enterocyte-like cell line, Caco-(2). These bacteria replicate in different compartments within the host cells; Salmonella serovar Typhimurium grow inside phagosomes, whereas L. monocytogenes escape the phagosomal environment and multiply in the cytosol of the host cells. At concentrations equal to 0.25 of the MIC and 4 times the MIC, respectively, FOM effectively decreased the number of intracellular Salmonella serovar Typhimurium. Although FOM was ineffective at inhibiting the extracellular growth of L. monocytogenes in vitro, this antibiotic induced a marked reduction in intracellular L. monocytogenes, indicating that, comparatively, FOM may be more effectively taken up by L. monocytogenes in the intracellular environment.
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