谷氨酸的
暴饮暴食
神经科学
抑制性突触后电位
下丘脑
生物神经网络
扁桃形结构
神经基质
外侧下丘脑
神经网络
生物
摄食行为
食物摄入量
弓状核
适应性行为
心理学
肥胖
医学
内分泌学
内科学
发展心理学
谷氨酸受体
认知
受体
作者
Joshua H. Jennings,Giorgio Rizzi,Alice M. Stamatakis,Randall L. Ung,Garret D. Stuber
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2013-09-27
卷期号:341 (6153): 1517-1521
被引量:394
标识
DOI:10.1126/science.1241812
摘要
The growing prevalence of overeating disorders is a key contributor to the worldwide obesity epidemic. Dysfunction of particular neural circuits may trigger deviations from adaptive feeding behaviors. The lateral hypothalamus (LH) is a crucial neural substrate for motivated behavior, including feeding, but the precise functional neurocircuitry that controls LH neuronal activity to engage feeding has not been defined. We observed that inhibitory synaptic inputs from the extended amygdala preferentially innervate and suppress the activity of LH glutamatergic neurons to control food intake. These findings help explain how dysregulated activity at a number of unique nodes can result in a cascading failure within a defined brain network to produce maladaptive feeding.
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