Recent advances in ultrasound-assisted extraction of natural products using novel solvents: a mini-review

A key factor in the successful extraction of natural products is the choice of solvent and mass transfer tool, which directly affects the efficiency, yield, selectivity, and quality of the natural products. However, the limitations of traditional solvents and the growing demand for more sustainable and efficient processes have driven interest in novel solvents. This shift is further encouraged by strict environmental regulations aimed at reducing emissions and avoiding hazardous chemicals. Ultrasound-assisted extraction (UAE) has emerged as a promising technique, enhancing yields and preserving compound quality through the cavitation phenomenon. Recent advancements combine ultrasound with novel solvents, showcasing their synergistic potential to further intensify natural product extraction. This review highlights the comparative performance of UAE and novel solvents, offering insights into their roles and challenges in achieving high-efficiency extraction. These findings aim to guide researchers, educators, and industry professionals toward sustainable and innovative extraction methods that align with environmental and industrial goals. • Novel solvents enhance extraction efficiency, sustainability, and UAE compatibility. • Focused on industrial needs for scalable, cost-effective, and green natural extraction. • Addressed current limitationsfor broader adoption in food, cosmetics, and pharmaceuticals.