效应器
生物
细胞生物学
细胞分化
免疫学
T细胞受体
先天性淋巴细胞
人口
炎症
T细胞
细胞因子
抗原
免疫系统
获得性免疫系统
医学
遗传学
基因
环境卫生
作者
Stanislav Dikiy,Aazam P. Ghelani,Andrew G. Levine,Stephen Martis,Paolo Giovanelli,Zhong-Min Wang,Giorgi Beroshvili,Yuri Pritykin,Chirag Krishna,Xiao Jun Huang,Ariella Glasner,Benjamin D. Greenbaum,Christina S. Leslie,Alexander Y. Rudensky
标识
DOI:10.1038/s41590-024-02075-6
摘要
Regulatory T (Treg) cells are a specialized CD4+ T cell lineage with essential anti-inflammatory functions. Analysis of Treg cell adaptations to non-lymphoid tissues that enable their specialized immunosuppressive and tissue-supportive functions raises questions about the underlying mechanisms of these adaptations and whether they represent stable differentiation or reversible activation states. Here, we characterize distinct colonic effector Treg cell transcriptional programs. Attenuated T cell receptor (TCR) signaling and acquisition of substantial TCR-independent functionality seems to facilitate the terminal differentiation of a population of colonic effector Treg cells that are distinguished by stable expression of the immunomodulatory cytokine IL-10. Functional studies show that this subset of effector Treg cells, but not their expression of IL-10, is indispensable for colonic health. These findings identify core features of the terminal differentiation of effector Treg cells in non-lymphoid tissues and their function.
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