New insights into the pathogenesis and treatment of senile osteoporosis: a narrative review

As life expectancy increases worldwide, diseases associated with aging are becoming an increasing challenge in medical care. One of them is senile osteoporosis, which often leads to fragility fractures and numerous subsequent complications, such as disability, chronic pain, and even death. Although osteoporosis is common in the elderly, data on its epidemiology, pathogenesis, and treatment are still lacking. Moreover, it is often diagnosed and treated only after a fracture occurs, which is associated with a significant reduction in quality of life and the generation of high costs. A better understanding of the pathomechanisms of senile osteoporosis is essential for early diagnosis, prevention, and the development of new therapies. This article reviewed current medical knowledge on osteoporosis in the elderly and its epidemiology, etiopathogenesis, diagnosis, and treatment.