细胞毒性T细胞
肿瘤微环境
CD8型
免疫疗法
免疫系统
癌症研究
微泡
细胞外小泡
免疫学
生物
细胞生物学
体外
小RNA
生物化学
基因
作者
Zeyu Huang,Xuehui Li,Qinghao Guo,Yihang Zhou,Linlin Shi,Qingjin Cai,Shupei Tang,Qin Ouyang,Jie Zheng
标识
DOI:10.3389/fimmu.2024.1376962
摘要
Tumors pose a significant global public health challenge, resulting in numerous fatalities annually. CD8 + T cells play a crucial role in combating tumors; however, their effectiveness is compromised by the tumor itself and the tumor microenvironment (TME), resulting in reduced efficacy of immunotherapy. In this dynamic interplay, extracellular vesicles (EVs) have emerged as pivotal mediators, facilitating direct and indirect communication between tumors and CD8 + T cells. In this article, we provide an overview of how tumor-derived EVs directly regulate CD8 + T cell function by carrying bioactive molecules they carry internally and on their surface. Simultaneously, these EVs modulate the TME, indirectly influencing the efficiency of CD8 + T cell responses. Furthermore, EVs derived from CD8 + T cells exhibit a dual role: they promote tumor immune evasion while also enhancing antitumor activity. Finally, we briefly discuss current prevailing approaches that utilize functionalized EVs based on tumor-targeted therapy and tumor immunotherapy. These approaches aim to present novel perspectives for EV-based tumor treatment strategies, demonstrating potential for advancements in the field.
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