面筋
介绍(产科)
疾病
医学
光谱(功能分析)
广谱
内科学
化学
病理
物理
放射科
量子力学
组合化学
作者
Dawn W. Adams,Stephanie Moleski,Jacqueline Jossen,Jason A. Tye‐Din
标识
DOI:10.1053/j.gastro.2024.01.052
摘要
Abstract
Views on the clinical presentation and symptomatology of celiac disease have evolved alongside advances in disease detection and understanding of disease pathogenesis. While historically regarded a pediatric illness characterized by malabsorption, it is now better viewed as an immune illness of gluten-specific T cells with systemic manifestations affecting all ages. Its broad presentation, including frequent extraintestinal manifestations and asymptomatic disease, contributes to suboptimal disease detection. Adverse symptoms greatly impact patient quality of life and can result from chronic gluten exposure in untreated disease or those poorly responsive to the gluten free diet and can also present as acute symptoms after episodic gluten exposure. Functional gastrointestinal disease is a common comorbidity. Biomarkers like interleukin-2 that are highly sensitive and specific for celiac disease highlight a role for gluten-specific T cells in acute gluten symptomatology. A mechanistic understanding of symptoms will inform approaches to better measure and effectively treat them.
科研通智能强力驱动
Strongly Powered by AbleSci AI