咖啡因
CYP1A2
化学
体内
药理学
脂肪组织
去甲基化
饮食性肥胖
肥胖
新陈代谢
内分泌学
生物化学
生物
细胞色素P450
生物技术
胰岛素抵抗
基因表达
DNA甲基化
基因
作者
Ying-Cai Zhao,Le-Ping Li,Xiaoyue Li,Chengcheng Wang,Jinyue Yang,Changhu Xue,Yuming Wang,Tiantian Zhang
摘要
Sea cucumber saponins (SCSs) exhibit a unique structure and high bioactivities and might have specialized implications on caffeine metabolic process by altering the activity of N-demethylation enzyme CYP1A2. The present study aimed to clarify the effects of SCS on caffeine metabolism in vivo and in vitro, as well as the synergistic anti-obesity effect of SCS and caffeine on high-fat diet-induced obese mice.Results found that SCS administration significantly postponed the elimination rate of caffeine and its metabolites in vivo, and further study found CYP1A2-mediated caffeine metabolism was remarkably inhibited in a dose-dependent manner in vitro. The synergistic effect of the SCS and caffeine combination could decrease the total weight of white adipose tissue by 52% compared with high-fat diet-treated group.SCS could prolong caffeine action time, and the combination of the two substances exhibited joint action on high-fat diet-induced obese mice. These findings might provide a basis for the development of functional foods and potential application using the combination of SCS and caffeine. © 2022 Society of Chemical Industry.
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