医学
冲程(发动机)
孟德尔随机化
荟萃分析
内科学
尿酸
队列
随机化
队列研究
缺血性中风
随机对照试验
缺血
遗传学
生物
基因型
机械工程
遗传变异
工程类
基因
作者
Jiu Chang Zhong,Huan Cai,Zhizhong Zhang,Jinjing Wang,Lulu Xiao,Pan Zhang,Yi Xu,Wenqing Tu,Wusheng Zhu,Xinfeng Liu,Wen Sun
标识
DOI:10.1177/23969873231209620
摘要
The role of serum uric acid (UA) levels in the functional recovery of ischemic stroke remains uncertain. To evaluate whether UA could predict clinical outcomes in patients with ischemic stroke.A three-stage study design was employed, combining a large-scale prospective cohort study, a meta-analysis and a Mendelian randomization (MR) analysis. Firstly, we conducted a cohort study using data from the Nanjing Stroke Registry Program (NSRP) to assess the association between UA levels and 3-month functional outcomes in ischemic stroke patients. Secondly, the meta-analysis was conducted to integrate currently available cohort evidence. Lastly, MR analysis was utilized to explore whether genetically determined UA had a causal link to the functional outcomes of ischemic stroke using summary data from the CKDGen and GISCOME datasets.In the first stage, the cohort study included 5631 patients and found no significant association between UA levels and functional outcomes at 3 months after ischemic stroke. In the second stage, the meta-analysis, including 10 studies with 14,657 patients, also showed no significant association between UA levels and stroke prognosis. Finally, in the third stage, MR analysis using data from 6165 patients in the GISCOME study revealed no evidence of a causal relationship between genetically determined UA and stroke functional outcomes.Our comprehensive triangulation approach found no significant association between UA levels and functional outcomes at 3 months after ischemic stroke.
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