EFFECT OF RESISTANCE TRAINING ON T-CELL PROLIFERATION AND ACTIVITY IN FEMALES: INFLUENCE OF TRAINING STATUS.

120 High intensity aerobic exercise has been shown to depress certain components of the immune system, yet little is known about the immune response to resistance training. The purpose of this investigation was to determine the effect of an acute bout of high intensity resistance training on the T cell activity and proliferation in trained and untrained females. Seven untrained(UT) (age, 22.3±0.7 y; body mass, 58.6±1.1 kg) and five trained(TR) (age, 22.9±1.4 y; body mass, 59.4±2.3 kg) females performed 3 sets of 10 repetitions at 89 ± 5% (UT) and 88 ± 3% (TR) of their 10 repetition maximum for seven exercises (4 upper body and 3 lower body). Blood was collected pre-exercise (PRE-EX) and 3 h post-exercise(POST-3) and analyzed for T cell activity and proliferative response through exposure to phytohemagglutanin (PHA). Significance was set at p<0.05. The results showed a significant decrease in T cell proliferation in response to PHA for the UT subjects at POST-3 h. TableTableThe data indicate that UT females will experienced alterations in their T cell proliferative response following an acute bout of resistance training and this is likely due to the metabolic response to exercise.