生物传感器
蛋白质工程
基因工程
计算生物学
纳米技术
计算机科学
蛋白质设计
作者
Alison C Leonard,Timothy A. Whitehead
标识
DOI:10.1016/j.copbio.2022.102787
摘要
Genetically encoded protein biosensors controlled by small organic molecules are valuable tools for many biotechnology applications, including control of cellular decisions in living cells. Here, we review recent advances in protein biosensor design and engineering for binding to novel ligands. We categorize sensor architecture as either integrated or portable, where portable biosensors uncouple molecular recognition from signal transduction. Proposed advances to improve portable biosensor development include standardizing a limited set of protein scaffolds, and automating ligand-compatibility screening and ligand-protein-interface design.
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