神经科学
药物发现
电压依赖性钙通道
生物
去极化
离子通道
钙信号传导
钙
细胞生物学
生物信息学
医学
信号转导
生物物理学
受体
生物化学
内科学
作者
Xia Yao,Shuai Gao,Nieng Yan
出处
期刊:Channels
[Informa]
日期:2023-12-07
卷期号:18 (1)
标识
DOI:10.1080/19336950.2023.2290807
摘要
Voltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane depolarization, playing critical roles in diverse physiological processes. Dysfunction or aberrant regulation of Cav channels can lead to life-threatening consequences. Cav-targeting drugs have been clinically used to treat cardiovascular and neuronal disorders for several decades. This review aims to provide an account of recent developments in the structural dissection of Cav channels. High-resolution structures have significantly advanced our understanding of the working and disease mechanisms of Cav channels, shed light on the molecular basis for their modulation, and elucidated the modes of actions (MOAs) of representative drugs and toxins. The progress in structural studies of Cav channels lays the foundation for future drug discovery efforts targeting Cav channelopathies.
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