Reactive Oxygen Species Modulator 1 Plays an Obligate Role in Cardiomyocyte Hypertrophy

HomeCirculation ResearchVol. 134, No. 1Reactive Oxygen Species Modulator 1 Plays an Obligate Role in Cardiomyocyte Hypertrophy No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextReactive Oxygen Species Modulator 1 Plays an Obligate Role in Cardiomyocyte Hypertrophy Matthew D. Martens, Claudia D. Holody, Lisa Wells, Heidi L. Silver, Daniela Y. Morales-Llamas, William W. Du, Courtney Reeks, Mostafa Khairy, Huachen Chen, Mourad Ferdaoussi, Stephane L. Bourque, Burton B. Yang, John R. Ussher, Hélène Lemieux, Gavin Y. Oudit, Robert A. Screaton and Jason R.B. Dyck Matthew D. MartensMatthew D. Martens https://orcid.org/0000-0001-9251-6693 Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , Claudia D. HolodyClaudia D. Holody https://orcid.org/0000-0003-1479-3809 Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Anesthesiology (C.D.H., S.L.B.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , Lisa WellsLisa Wells Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada. Department of Biochemistry (L.W., C.R., R.A.S.), University of Toronto, Ontario, Canada. , Heidi L. SilverHeidi L. Silver Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , Daniela Y. Morales-LlamasDaniela Y. Morales-Llamas Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , William W. DuWilliam W. Du Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada. Department of Laboratory Medicine and Pathobiology (W.W.D., B.B.Y.), University of Toronto, Ontario, Canada. , Courtney ReeksCourtney Reeks https://orcid.org/0009-0002-2451-3532 Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada. Department of Biochemistry (L.W., C.R., R.A.S.), University of Toronto, Ontario, Canada. , Mostafa KhairyMostafa Khairy Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , Huachen ChenHuachen Chen https://orcid.org/0000-0003-3542-0884 Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , Mourad FerdaoussiMourad Ferdaoussi https://orcid.org/0000-0001-7636-0959 Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Faculty Saint-Jean (M.F., H.L.), University of Alberta, Edmonton, Canada. , Stephane L. BourqueStephane L. Bourque Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Anesthesiology (C.D.H., S.L.B.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , Burton B. YangBurton B. Yang https://orcid.org/0000-0002-2892-7209 Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada. Department of Laboratory Medicine and Pathobiology (W.W.D., B.B.Y.), University of Toronto, Ontario, Canada. , John R. UssherJohn R. Ussher https://orcid.org/0000-0001-9574-5707 Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), University of Alberta, Edmonton, Canada. , Hélène LemieuxHélène Lemieux Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Faculty Saint-Jean (M.F., H.L.), University of Alberta, Edmonton, Canada. , Gavin Y. OuditGavin Y. Oudit https://orcid.org/0000-0002-9154-9028 Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. , Robert A. ScreatonRobert A. Screaton Correspondence to: Robert A. Screaton, PhD, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M7 617, Toronto, ON, Canada, M4N 3M5, Email E-mail Address: [email protected] https://orcid.org/0000-0002-4917-9473 Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada. Department of Biochemistry (L.W., C.R., R.A.S.), University of Toronto, Ontario, Canada. and Jason R.B. DyckJason R.B. Dyck Jason R.B. Dyck, PhD, 458A Heritage Medical Research Centre, 11207 - 87 Ave NW, Edmonton, AB, Canada, T6G 2S2, Email E-mail Address: [email protected] Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Originally published29 Nov 2023https://doi.org/10.1161/CIRCRESAHA.123.323456Circulation Research. 2024;134:114–116FootnotesFor Sources of Funding and Disclosures, see page 116.Correspondence to: Robert A. Screaton, PhD, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M7 617, Toronto, ON, Canada, M4N 3M5, Email roblab@gmail.comJason R.B. Dyck, PhD, 458A Heritage Medical Research Centre, 11207 - 87 Ave NW, Edmonton, AB, Canada, T6G 2S2, Email jason.dyck@ualberta.caReferences1. Norton M, Ng AC, Baird S, Dumoulin A, Shutt T, Mah N, Andrade-Navarro MA, McBride HM, Screaton RA. ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.Sci Signal. 2014; 7:ra10. doi: 10.1126/scisignal.2004374CrossrefMedlineGoogle Scholar2. Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, et al. ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.J Cell Biol. 2019; 218:598–614. doi: 10.1083/jcb.201806093CrossrefMedlineGoogle Scholar3. Bhandari P, Song M, Dorn GW. Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects.J Mol Cell Cardiol. 2015; 80:71–80. doi: 10.1016/j.yjmcc.2014.12.018CrossrefMedlineGoogle Scholar4. Chung YM, Kim JS, Yoo YD. A novel protein, Romo1, induces ROS production in the mitochondria.Biochem Biophys Res Commun. 2006; 347:649–655. doi: 10.1016/j.bbrc.2006.06.140CrossrefMedlineGoogle Scholar5. Maulik SK, Kumar S. Oxidative stress and cardiac hypertrophy: a review.Toxicol Mech Methods. 2012; 22:359–366. doi: 10.3109/15376516.2012.666650CrossrefMedlineGoogle Scholar eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. 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