In order to increase the heavy-duty AGV load capacity to 60t, this paper proposes a design scheme of AGV frame structure based on the working demand of AGV workshop; based on the designed heavy-duty AGV frame structure, a finite element model of the frame structure is established, and the static simulation of the AGV frame is carried out to get the stress distribution and deformation under the full-loaded working condition. Through the dynamic performance analysis of the AGV frame, the 7th to 12th order modal frequencies and vibration pattern diagrams of the frame are obtained, and the results show that the dynamic performance of the AGV is good, and the frequencies of each order are greater than the road excitation, and no resonance damage will occur.