Cobalt‐Catalyzed Allylic Defluorinative Cross‐Electrophile Coupling between 1,1‐Difluoroalkyl Halides and α‐Trifluoromethyl Styrenes

Abstract In this protocol, we apply reductive cobalt catalysis in the allylic defluorinative cross‐electrophile coupling reaction between 1,1‐difluoroalkyl halides and α‐trifluoromethyl styrenes. This reaction features broad substrate scope (39 examples), good tolerance of various functionalities, and circumvention of pregenerating organometallics, offering a general synthetic route to prepare diverse organofluorines incorporating both a gem‐difluoroalkene and a gem‐difluoroalkane moiety. magnified image