妊娠期糖尿病
队列
糖尿病
重金属
医学
Mercury(编程语言)
硒
队列研究
环境卫生
泊松回归
产科
怀孕
四分位数
锰
混淆
甲基汞
流行病学
胎龄
黑人妇女
风险评估
出生证明
风险因素
妊娠期
汞暴露
生理学
作者
Zeyu Li,Guoying Wang,Xiumei Hong,Stephen P. Juraschek,Long Ngo,Xiaobin Wang,Mingyu Zhang
标识
DOI:10.1021/acs.est.5c08219
摘要
We investigated the associations of pregnancy levels of heavy metals and trace elements with the risk of gestational diabetes mellitus (GDM). Participating pregnant women were from the Boston Birth Cohort. We measured levels of mercury, lead, cadmium, selenium, and manganese in maternal red blood cells collected after delivery. We verified the GDM diagnosis using ICD codes, medication history, and plasma glucose profile abstracted from medical records. We used modified Poisson regression and Bayesian kernel machine regression models to examine associations of metals and elements, individually and as a mixture, with GDM. We stratified the analyses by race and ethnicity. Among 1256 pregnant women, 58% were non-Hispanic Black and 22% were Hispanic. Overall, each doubling of mercury and manganese levels was associated with 1.14 (95% CI: 1.01-1.28) and 0.65 (95% CI: 0.50-0.84) times the risk of GDM, respectively. In the race- and ethnicity-stratified analyses, the mercury-GDM association was stronger among Black women, and higher selenium levels were associated with higher GDM risk only among Hispanic women (Pinteraction = 0.01). In conclusion, women with higher mercury or lower manganese levels during pregnancy were more likely to develop GDM. An increased GDM risk associated with higher selenium levels was observed only in Hispanic women.
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