光动力疗法
活性氧
阿霉素
化学
光敏剂
环糊精
胶束
肿瘤微环境
细胞凋亡
生物物理学
癌症研究
组合化学
化疗
光化学
生物化学
有机化学
肿瘤细胞
医学
水溶液
外科
生物
作者
Die Jia,Xianbin Ma,Yi Lu,Xinyi Li,Shengxin Hou,Yuan Gao,Peng Xue,Yuejun Kang,Zhigang Xu
标识
DOI:10.1016/j.cclet.2020.11.052
摘要
Cyclodextrin (CD) has special spatial structure and well biological safety, so it has been widely used for constructing CD-based nanoplatforms. Through functionalization, cyclodextrin can form various stimulus-response nanoplatforms, such as pH, temperature, redox, light and magnetic fields. In this study, we designed a highly sensitive reactive oxygen species (ROS)-responsive polymer PCP which encapsulated doxorubicin (DOX) and purpurin 18 (P18) to achieve the synergy of photodynamic and chemotherapy. The high content of reactive oxygen species (ROS) in the tumor microenvironment (TME) triggers the cleavage of the borate bond of MPEG-CD-PHB (PCP), thereby promoting the release of drugs. When irradiated with near-infrared laser, the photosensitizer P18 released by polymer micelles can produce reactive oxygen species to promote cell apoptosis. Compared with monotherapy, a series of experiments confirmed that our micelles had enhanced anti-cancer activity. This work was beneficial to the design of ROS-responsive materials and provides an effective strategy for the application of collaborative anti-tumor therapy.
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