RNA结合蛋白
翻译(生物学)
生物
基因表达
Rna处理
核糖核酸
信使核糖核酸
白血病
计算生物学
基因表达调控
基因
细胞生物学
遗传学
作者
Irina Elcheva,Vladimir S. Spiegelman
出处
期刊:Leukemia
[Springer Nature]
日期:2020-11-04
卷期号:35 (2): 360-376
被引量:17
标识
DOI:10.1038/s41375-020-01066-4
摘要
RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.
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