生物
祖细胞
细胞命运测定
造血
否定选择
细胞
祖细胞
细胞生物学
淋巴细胞生成
细胞生长
基因
T细胞
干细胞
免疫学
遗传学
转录因子
免疫系统
基因组
作者
Chen Liu,Yu Lan,Bing Liu,Huiyuan Zhang,Hongbo Hu
标识
DOI:10.1016/j.it.2020.12.004
摘要
Mammalian T cell development initiates from the migration of hematopoietic progenitors to the thymus, which undergo cell proliferation, T-lineage specification and commitment, as well as positive and negative selection. These processes are precisely controlled at multiple levels and have been intensively studied using gene-modified animal models and in vitro coculture systems. However, several long-standing questions, including the characterization of the rare but crucial progenitors/precursors and the molecular mechanisms underlying their fate decision, have been dampened because of cell scarcity and lack of appropriate techniques. Single-cell RNA sequencing (scRNA-seq) makes it possible to investigate and resolve some of these questions, leading to new remarkable progress in identifying and characterizing early thymic progenitors and delineating the refined developmental trajectories of conventional and unconventional T cells.
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