明胶
自愈水凝胶
傅里叶变换红外光谱
肿胀 的
材料科学
复合数
扫描电子显微镜
多孔性
复合材料
组织工程
变形(气象学)
化学工程
生物医学工程
高分子化学
化学
医学
工程类
生物化学
作者
Yu Jiang,Gaiying Li,Jie Liu,Mengya Li,Qian Li,Keyong Tang
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2021-01-22
卷期号:4 (2): 1536-1543
被引量:14
标识
DOI:10.1021/acsabm.0c01400
摘要
In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG). The process of OKG was first optimized by adjusting parameters, that is, oxidation temperature and time during processing. Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs). These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests. In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height). Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells. In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
科研通智能强力驱动
Strongly Powered by AbleSci AI