化学
曼尼希反应
产量(工程)
甘氨酸
催化作用
离子液体
磺酸
肺表面活性物质
有机化学
樟脑
氨基酸
生物化学
冶金
材料科学
作者
Somayeh Darvishy,Heshmatollah Alinezhad,Majid Vafaeezadeh,Sahar Peiman,Behrooz Maleki
标识
DOI:10.1080/10406638.2022.2094419
摘要
A rapid and efficient S-(+) camphor sulfonic acid Glycine (CSAG), catalyzed, one-pot three-component Mannich reaction has been performed to synthesize ß-amino carbonyl compound at room temperature. The reaction gave desired products in good yield and excellent diastereoselectivity. Products in the presence of CSAG (15 mol%) with yields of 52–89% were obtained. This method offers a new modification and easy working process in mild reaction conditions with a low amount and catalyst recyclability up to at least three periods without significant reduction in performance (efficiency 88–77%). This report describes for the first time the preparation of CSAG catalysts for the synthesis of Mannich products.
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