屎肠球菌
粪肠球菌
抗菌剂
三七
抗菌活性
微生物学
多重耐药
生物
抗真菌
真菌
细菌
抗生素
植物
金黄色葡萄球菌
医学
替代医学
病理
遗传学
作者
Peng‐Jie Xian,Shuzhi Liu,Wenjing Wang,Yang Shen,Feng Zhang,Xiao‐Long Yang
出处
期刊:Phytochemistry
[Elsevier]
日期:2022-10-01
卷期号:202: 113303-113303
被引量:6
标识
DOI:10.1016/j.phytochem.2022.113303
摘要
The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species. Their structures were confirmed by extensive spectroscopic data, single-crystal X-ray crystallography and quantum chemistry calculations. Emerlactam A exhibited better antibacterial activity against multidrug-resistant Enterococcus faecium and antifungal activity against Helminthosporium maydis, with an MIC value of 12.5 μg/mL. Quiannulatic acid displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium and multidrug-resistant Enterococcus faecalis with MIC values of 1.56 μg/mL and 3.13 μg/mL, respectively. 5-alkenylresorcinol exhibited significant antifungal activity against all tested phytopathogenic fungi with MIC values ranging from 6.25 to 12.5 μg/mL.
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