细胞生物学
JAK-STAT信号通路
斯达
贾纳斯激酶
细胞因子
信号转导
车站3
转录因子
细胞因子信号抑制因子1
生物
化学
免疫学
酪氨酸激酶
生物化学
基因
抑制器
作者
Rhiannon Morris,Nadia J. Kershaw,Jeffrey J. Babon
摘要
Abstract More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation, growth, or apoptosis of their target cells. They act by binding to specific receptors on the surface of target cells and switching on a phosphotyrosine‐based intracellular signaling cascade initiated by kinases then propagated and effected by SH2 domain‐containing transcription factors. As cytokine signaling is proliferative and often inflammatory, it is tightly regulated in terms of both amplitude and duration. Here we review molecular details of the cytokine‐induced signaling cascade and describe the architectures of the proteins involved, including the receptors, kinases, and transcription factors that initiate and propagate signaling and the regulatory proteins that control it.
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