斑马鱼
药物发现
纳米医学
再生(生物学)
药物开发
纳米载体
计算生物学
计算机科学
神经科学
生物
药品
生物信息学
纳米技术
药理学
细胞生物学
基因
纳米颗粒
材料科学
生物化学
作者
David T. White,Mohit Saxena,Jeff S. Mumm
标识
DOI:10.1016/j.addr.2019.01.011
摘要
Several key attributes of zebrafish make them an ideal model system for the discovery and development of regeneration promoting therapeutics; most notably their robust capacity for self-repair which extends to the central nervous system. Further, by enabling large-scale drug discovery directly in living vertebrate disease models, zebrafish circumvent critical bottlenecks which have driven drug development costs up. This review summarizes currently available zebrafish phenotypic screening platforms, HTS-ready neurodegenerative disease modeling strategies, zebrafish small molecule screens which have succeeded in identifying regeneration promoting compounds and explores how intravital imaging in zebrafish can facilitate comprehensive analysis of nanocarrier biodistribution and pharmacokinetics. Finally, we discuss the benefits and challenges attending the combination of zebrafish and nanoparticle-based drug optimization, highlighting inspiring proof-of-concept studies and looking toward implementation across the drug development community.
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