病毒学
抗原
获得性免疫系统
细胞内寄生虫
先天免疫系统
免疫
抗体
细胞内
作者
Robert A. Seder,Adrian V. S. Hill
出处
期刊:Nature
[Springer Nature]
日期:2000-08-17
卷期号:406 (6797): 793-798
被引量:321
摘要
Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for diseases such as HIV, malaria and tuberculosis, in which the cellular immune response might be crucial in mediating protection. Here we examine the mechanisms by which long-lived cellular immune responses are generated and maintained in vivo. We then discuss current approaches for vaccination against diseases in which cellular immune responses are important for protection.
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