Metal Halide Perovskite Quantum Dots for Luminescence Sensing and Imaging

ABSTRACT Metal halide perovskite quantum dots (PQDs) exhibit strong optical absorption, high photoluminescence quantum yields, spectrally narrow and adjustable emission, and high defect tolerance. However, enhancing their stability in aqueous solution and improving their analytical performance remain critical challenges for the development of sensors for biological and chemical analytes. Stability and reproducibility in aqueous and physiological media are paramount for functional biosensing and bioimaging. Thus, most studies have focused on the analysis of chemicals in food safety, chemical product quality control, and industry process monitoring, whereas molecular diagnostics and cellular imaging have mainly remained in a proof‐of‐concept stage. In this study, we review applications of PQDs in luminescence sensing and imaging. After a brief introduction of PQD structure, synthesis, stability, and optical properties, we focus on applications of PQD‐based sensing via photoluminescence, chemiluminescence, and electroluminescence, as well as their use in luminescence imaging. We discuss current challenges, potential solutions, and future opportunities for developing PQD‐based sensing platforms.