自愈水凝胶
生物相容性
透明质酸
材料科学
伤口愈合
药物输送
复合数
生物医学工程
壳聚糖
纳米纤维
姜黄素
生物物理学
药理学
纳米技术
化学
高分子化学
生物化学
外科
医学
复合材料
冶金
解剖
生物
作者
Ling Wang,Jing Li,Yue Xiong,Yihang Wu,Fen Yang,Ying Guo,Zhaolin Chen,Liqian Gao,Wenbin Deng
标识
DOI:10.1021/acsami.1c16738
摘要
Peptide hydrogels are widely used for biomedical applications owing to their good biocompatibility and unique advantages in terms of amino acid-based structures and functions. However, the exploration of the peptide/saccharide composite hydrogels as potential biomaterials for chronic diabetic wound healing is still limited. Herein, hyaluronic acid (HA) was incorporated into diphenylalanine (FF) conjugated with different aromatic moieties by a one-pot reaction. Our results showed that the dipeptide derivatives modified by benzene (B), naphthalene (N), and pyrene (P) self-assembled into composite hydrogels with uniform distribution and good mechanical properties in the presence of HA. The obtained N-FF/HA composite hydrogel exhibited greatly improved self-healing properties via injection syringe needle operation and good biocompatibility on human skin fibroblast (HSF) cells. Besides, the structure of thinner nanofibers and honeycomb networks inside the composite hydrogel allowed for a longer sustained release of curcumin, a hydrophobic drug for anti-inflammation and wound healing. The curcumin-loaded N-FF/HA composite hydrogels could promote chronic wound healing in the streptozotocin-induced type I diabetic mouse model. The results suggested that our developed saccharide-peptide hydrogels could serve as very promising synthetic biomaterials for applications in both drug delivery and wound healing in the future.
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