透皮
溶解
聚乙烯醇
材料科学
药物输送
药品
壳聚糖
聚合物
海藻酸钠
明胶
药理学
纳米技术
化学
钠
复合材料
有机化学
医学
冶金
作者
Qi Lei Wang,Jia Wei Ren,Bo Zhi Chen,Jin Xu,Can Yang Zhang,Xin Dong Guo
标识
DOI:10.1016/j.jiec.2017.10.030
摘要
Dissolving microneedles (DMNs) prepared from soluble polymers has been being widely investigated as a safe and effective transdermal delivery system for drug and vaccine. Limited by the materials, the air humidity would probably affect the mechanical property of DMNs, which is essential for the effective needle insertions and drug delivery. In this study, four kinds DMNs prepared by polyvinyl alcohol, sodium hyaluronate (HA), chitosan and gelatin are studied on the mechanical strength and insertion ability under varying humidity conditions. Based on these investigations, we hope to provide the effective time of DMNs to ensure a successful insertion and drug delivery.
科研通智能强力驱动
Strongly Powered by AbleSci AI