Urban Fine Particulate Matter and Elements Associated with Subclinical Atherosclerosis in Adolescents and Young Adults

The relationships between the elemental constituents of PM_2.5 and atherosclerosis remain limited, especially in young populations. This study included 755 subjects aged 12-30 years in the Taipei metropolis. A land use regression model was used to estimate residential annual mean concentrations of PM_2.5 and eight elemental constituents. We evaluated the percent differences in carotid intima-media thickness (CIMT) with PM_2.5 and elemental constituent exposures by linear regressions. Interquartile range increments for PM_2.5 (4.5 μg/m³), sulfur (108.6 ng/m³), manganese (2.0 ng/m³), iron (34.5 ng/m³), copper (3.6 ng/m³), and zinc (20.7 ng/m³) were found to associate with 0.92% (95% confidence interval (CI): 0.17-1.66), 0.51% (0.02-1.00), 0.36% (0.05-0.67), 0.98% (0.15-1.82), 0.74% (0.01-1.48), and 1.20% (0.33-2.08) higher CIMTs, respectively. Factor analysis identified four air pollution source-related factors, and the factors interpreted as traffic and industry sources were associated with higher CIMTs. Stratified analyses showed the estimates were more evident in subjects who were ≥18 years old, females, or who had lower household income. Our study results provide new insight into the impacts of source-specific air pollution, and future research on source-specific air pollution effects in young populations, especially in vulnerable subpopulations, is warranted.