表观遗传学
疾病
小RNA
DNA甲基化
组蛋白
病态的
阿尔茨海默病
表观遗传疗法
神经科学
医学
生物信息学
发病机制
生物
遗传学
病理
基因
基因表达
作者
Xiaodie Gao,Qiang Chen,Hua Yang,Jie Tan,Zheng Liu,Yan Zhou,Zhenyou Zou
标识
DOI:10.3389/fnagi.2022.911635
摘要
Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and complex pathological manifestations. At present, a large number of studies on targeted drugs for the typical pathological phenomenon of AD (Aβ) have ended in failure. Although there are some drugs on the market that indirectly act on AD, their efficacy is very low and the side effects are substantial, so there is an urgent need to develop a new strategy for the treatment of AD. An increasing number of studies have confirmed epigenetic changes in AD. Although it is not clear whether these epigenetic changes are the cause or result of AD, they provide a new avenue of treatment for medical researchers worldwide. This article summarizes various epigenetic changes in AD, including DNA methylation, histone modification and miRNA, and concludes that epigenetics has great potential as a new target for the treatment of AD.
科研通智能强力驱动
Strongly Powered by AbleSci AI