介孔材料
材料科学
纳米技术
涂层
吸附
介孔二氧化硅
药物输送
复合数
钛
化学工程
复合材料
化学
催化作用
冶金
有机化学
工程类
作者
Mengli Liu,Fang Huang,Chin‐Te Hung,Liwei Wang,Wei Bi,Yupu Liu,Wei Li
出处
期刊:Nano Research
[Springer Nature]
日期:2022-01-22
卷期号:15 (5): 4243-4250
被引量:6
标识
DOI:10.1007/s12274-021-4055-y
摘要
Implant-associated bacterial infection remains one of the most common and serious complications. Therefore, a surface boasting long-term antibacterial ability for implants is highly desirable. Herein, mesoporous silica coatings (MSCs) with vertical and size-tunable mesochannels are fabricated on a variety of metal substrates via a nano-interfacial oriented assembly approach. Such facile and versatile approach relies on the vertically oriented fusion of composite micelles on the nanoscale flatness surface of substrates. Such orientation assembly process endows the MSCs with vertical mesochannels, tunable mesopore size (ca. 5.5–13.5 nm), and switchable substrates even with complex and diversified surfaces. Importantly, the MSCs on titanium substrates (Ti@MSCs) exhibit excellent performances for drug adsorption and sustained release. The saturation adsorption capacity can reach 0.544 µg·cm−2 towards minocycline hydrochloride (MC-HCl) antibiotic molecules, which is 6.5 times as the bare titanium (Ti) substrate. In addition, the drug release time can be controlled from 84 to 216 h by simply adjusting the mesopore size. As a proof of concept, the Ti@MSCs can realize a higher antibacterial rate (95.9%), compared with the bare Ti (70.3%). The results highlight the high potential of MSCs as implant coating for long-term preventing and eliminating peri-implantitis.
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