CTQ树
哈姆德
重性抑郁障碍
萧条(经济学)
心理学
调解
额上回
医学
内科学
精神科
毒物控制
伤害预防
认知
显著性差异
扁桃形结构
家庭暴力
法学
经济
宏观经济学
环境卫生
政治学
作者
Yahui Liu,Jiajia Zhang,Meng Zhang,Xianrui Li,Kun Li,Wang Bi,Yongfeng Yang,Ruize Song,Yajing Si,Tianjun Ni,Xueke Wang,Yibo Geng,Qiaohua Chang,Haisan Zhang,Zhijun Zhang,Hongxing Zhang
标识
DOI:10.1016/j.jad.2022.04.083
摘要
Patients with major depressive disorders (MDD) have abnormalities in the frontal-limbic structures of the brain. Childhood trauma is a risk factor for both structural brain alterations and MDD. However, the relationships among the three have not been confirmed.Sixty-four patients with MDD and sixty-one healthy controls (HC) were checked by using MRI, the Hamilton Depression Scale (HAMD) and Childhood Trauma Questionnaire (CTQ). Voxel-based morphometry (VBM) was used to compare gray matter volume (GMV) differences between the two groups. Moreover, partial correlation and mediation analyses were conducted to test for potential associations between CTQ scores, different GMV, and clinical variables.Compared to the HC group, the MDD patients showed decreased GMV in the right middle frontal gyrus (rMFG) and right precentral gyrus (rPreCG). In the patient group, reduced GMV in rMFG was associated with CTQ scores (r = -0.30, P = 0.019) and HAMD scores (r = -0.53, P < 0.001). Finally, in the patient group, mediation analysis revealed that the indirect effect of rMFG GMV in CTQ scores and HAMD scores was 0.115 and the proportion of indirect effect to total effect was 23.86%.This study used a cross-sectional collection, and it is unclear whether at the longitudinal level the brain GMV mediates the relationship between childhood trauma and depression.Abnormalities in the frontal GMV were presented in the MDD patients. It is possible that childhood traumatic experiences cause inefficient GMV and ultimately lead to an increased susceptibility to depression.
科研通智能强力驱动
Strongly Powered by AbleSci AI