卤化物
催化作用
电泳剂
化学
镍
烷基
惰性气体
金属
锰
锌
过渡金属
偶联反应
惰性
无机化学
有机化学
作者
Andrew C. Jones,Matthew Williams,Louis C. Morrill,Duncan L. Browne
出处
期刊:ACS Catalysis
日期:2022-10-25
卷期号:12 (21): 13681-13689
被引量:14
标识
DOI:10.1021/acscatal.2c03117
摘要
The cross-electrophile coupling of either twisted-amides or heteroaryl halides with alkyl halides, enabled by ball-milling, is herein described. The operationally simple nickel-catalyzed process has no requirement for inert atmosphere or dry solvents and delivers the corresponding acylated or heteroarylated products across a broad range of substrates. Key to negating the necessity of inert reaction conditions is the mechanical activation of the raw metal terminal reductant: manganese in the case of twisted amides and zinc for heteroaryl halides.
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