化学
磺酰
氟
咪唑
硫黄
氟化物
氟化钾
有机化学
组合化学
无机化学
烷基
作者
Marco T. Passia,Joachim Demaerel,Mostafa M. Amer,Alwin Drichel,S Zimmer,Carsten Bolm
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-23
卷期号:24 (48): 8802-8805
被引量:6
标识
DOI:10.1021/acs.orglett.2c03546
摘要
Sulfur(VI) fluoride motifs are important entities in organic chemistry. Typically, their syntheses involve the corresponding chlorides, which are often difficult to prepare and characterized by a poor storability due to the inherently weak S-Cl bond. Here, a single-step procedure for the preparation of sulfur(VI) fluorides starting from sulfonyl imidazoles as stable S(VI) reservoirs is described. By using a simple combination of AcOH and potassium bifluoride (KF2H), an imidazole-to-fluorine exchange furnishes a variety of sulfonyl, sulfonimidoyl, sulfoxyl, and sulfamoyl fluorides in good to excellent yields.
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